Bioavailability

Bioavailability corresponds to the amount of active ingredient of a formulation (of a supplement or drug) made available in the systemic circulation and the time and speed it takes to reach its maximum concentration after administration to be functional.

Bioavailability is certainly the index that best allows us to understand the functionality of a product in relation to its content. The task of our laboratories is to develop innovative formulation technologies capable of optimising this process.

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The bioavailability of a formulation is largely determined by the characteristics of the pharmaceutical form and dosage which also depend on its design and manufacturing process. Additionally, bioavailability can be affected by a number of other factors, including:

  • - the quality of the raw materials and active ingredients used in the supplement formulation;
  • - the integration between the substances contained within the supplement;
  • - the format of the supplement (tablets, granules);
  • - interactions with other substances present in the body;
  • - intake during meals.


When our researchers approach new therapeutic needs, they start from a precise analysis of the underlying biological mechanisms. Next, they study how the active ingredient can affect these mechanisms. Thus formulations with high bioavailability and high molecular weight are developed, which are then further optimised and tested, to ensure maximum therapeutic efficacy.


The action of each supplement will undoubtedly also depend on the condition of the organism that takes it. Each human being is different from the other, so they will absorb the active ingredients contained in supplements in a different way.

Science Informs: The River Pharma Blog

Menopause and osteoporosis: what causes bone loss?

Menopause and osteoporosis: what causes bone loss?

18 July 2022
8 min.

Unfortunately for all women who are in menopause osteoporosis is a sad reality that sooner or later will become increasingly present in their lives, this is even more true in all those who already have a genetic predisposition towards this degenerative bone disease.

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