Reducing the risk of fractures with Calcium and Vitamin D
Calcium and Vitamin D therapy has been recommended for older persons, with key risk factors including decreased bone mineral density (BMD), osteoporotic fractures, increased bone remodelling as a result of secondary hyperparathyroidism and increased propensity to falls. […] Integration of Calcium and Vitamin D is a key component in the prevention and treatment of osteoporosis. […] Based on the relationship between serum 25(OH)D – dihydroxycholecalciferol, the active form of vitamin D3, BMD, bone turnover, we suggest that 50 nmol/l is the appropriate serum 25(OH)D threshold to define vitamin D insufficiency. Supplementation should therefore generally aim to increase 25(OH)D levels within the 50-75 nmol/l range. This level can be achieved with a dose of 800 IU/day of vitamin D […], the dose that was used in successful fracture prevention […]
Osteoporotic fractures are a growing health problem […]. The risk of fracture increases exponentially with age and with a decrease in bone mineral density (BMD), often associated with increased bone remodelling rate, resulting in a net bone reabsorption and a subsequent decrease of bone strength.
[…] The supplement of Calcium and Vitamin D in elderly individuals with a poor nutritional status, can reduce bone resorption, increase bone mineral density and reduce the risk of fractures.
[…] In conclusion, a low intake of Calcium and a poor Vitamin D status are key factors for osteoporosis and fracture risk. The supplement of Calcium and Vitamin D is an essential component in the prevention and treatment of osteoporosis and osteoporotic fractures. It improves bone mineralization […].
The supplement should guarantee the increase in levels of dihydroxycholecalciferol in the 50-75 nmol/l range. This target can be reached with a daily dose of 800 IU of Vitamin D, the dose used in many successful studies on the prevention of fractures. […] The calcium balance can be optimized with daily intakes of Calcium […].
Paul Lips, Roger Bouillon, Natasja M. van Schoor, Dirk Vanderschueren, Sabine Verschueren, Natalia Kuchuk, Koen Milisen, and Steven Boonen: Reducing fracture risk with Calcium and Vitamin D. Clinical Endocrinology.