Hyaluronic Acid retains its biological activity when taken orally.


Oral administration of Hyaluronic Acid polymer alleviates the symptoms of osteoarthritis in the knees: double-blind, placebo-control trial for a period exceeding 12 months


Osteoarthritis (OA) is a disease characterised by a gradual loss of cartilage which extends over years and decades. […] Although OA can affect any synovial joint, OA of knee joints is the most cumbersome in terms of prevalence and disability. […] Hyaluronic Acid (HA) is a mucopolysaccharide comprised of repeats of D-glucuronic acid and N-acetylglucosamine. It is abundantly present in the synovial fluid. […] Compared with steroids, HA placed into joints may work more slowly, but its effect may last considerably longer. […]

Material and Methods

The  study was conducted as a randomised double-blind placebo-controlled trial. The 60 subjects

enrolled in the study were assigned to either the HA or the placebo group, […]. Subjects in the HA group were requested to ingest 4 hard capsules containing a total of 200 mg of HA once a day after breakfast, everyday for 12 months. In the placebo group, subjects were asked to take 4 hard capsules which contained only cornstarch. […]

In this study, patients’ symptoms were evaluated by the Japanese Knee Osteoarthritis Measures (JKOM) score, […]. The symptoms of the subjects were recorded immediately before and at 2, 4, 6, and 12 months after the initial capsule administration, […].


In the present study, HA was administered orally. Therefore, it is crucial that the orally administered HA is actually absorbed and distributed to the knee joints while retaining its biological activities.. […] A series of experiments using radiolabelled HA indicated that orally administered HA would be indeed absorbed and distributed to the skin, bone, and synovial joints and would be retained in those tissues for prolonged periods. […] The result of this study in which HA was orally administered over a 12-month period revealed a possibility that HA may alleviate knee OA symptoms in relatively young subjects […]

Toshiyuki Tashiro, Satoshi Seino, Toshihide Sato, RyosukeMatsuoka, YasunobuMasuda and Naoshi Fukui: Oral Aministration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period. The Scientific World Jornal.